PDE5-inhibitor tablets for erectile dysfunction
This combo merges sildenafil’s fast action with tadalafil’s long duration for continuous erectile support. The combination is recommended primarily for experienced users who understand its specific risks.
Sildenafil and tadalafil are phosphodiesterase type-5 (PDE5) inhibitors that enhance blood flow to the penis to make an erection easier to get and keep during sexual arousal. When you are sexually stimulated, your body releases nitric oxide, and these medications work by blocking the enzyme that breaks down the signal responsible for relaxing blood vessels. While sildenafil provides fast-acting support, tadalafil’s defining feature is its duration, often lasting considerably longer as a "weekend" treatment. Neither medication acts as an aphrodisiac, meaning they both strictly require natural sexual arousal to function and will not cause an erection on their own.
Do not take Sildenafil+Tadalafil if you use any nitrate medicine for chest pain or heart problems (such as nitroglycerin, isosorbide dinitrate or mononitrate), recreational nitrites (“poppers”), or the pulmonary-hypertension medicine riociguat (Adempas). Together they can cause a sudden, life-threatening drop in blood pressure.
Vardenafil can affect heart rhythm (QT interval), so it should be avoided if you have certain heart-rhythm conditions or take some antiarrhythmic medicines. Tell the prescriber if you take alpha-blockers , or certain antifungal, HIV or antibiotic medicines (CYP3A4 inhibitors), or have heart disease, low or high blood pressure, severe liver or kidney problems, a recent stroke or heart attack, or a history of certain eye conditions. Vardenafil is for adults (18+) and is not for women or children.
Seek emergency care for an erection lasting more than 4 hours, sudden loss of vision or hearing, chest pain, or signs of an allergic reaction.
Most are mild and pass quickly. They include headache, facial flushing, a blocked or runny nose, indigestion, dizziness and back pain. Stop and contact a clinician if side effects are severe or persistent.
Active ingredient: tadalafil, 30 mg and sildenafil (as sildenafil citrate), 75mg per film-coated tablet. Inactive ingredients vary by licensed manufacturer and are listed in the patient information leaflet enclosed with every order.
Sources
The information on this page is summarised from the credible medical sources below. It’s general information only — always read the patient information leaflet enclosed with your medicine and follow your prescriber’s advice.
If you want to read other people’s real-world experiences, the r/ErectileDysfunction community on Reddit is an active, supportive place. Treat it as peer discussion only — it isn’t a clinical source, so always confirm anything important with the sources above or your prescriber.
Visit r/ErectileDysfunction →